Multimodal contrastive learning (MCL) has recently demonstrated significant success across various tasks. However, the existing MCL treats all negative samples equally and ignores the potential semantic association with positive samples, which limits the model's ability to achieve fine-grained alignment. In multi-view scenarios, MCL tends to prioritize shared information while neglecting modality-specific unique information across different views, leading to feature suppression and suboptimal performance in downstream tasks. To address these limitations, we propose a novel contrastive framework name QUEST: Quadruple Multimodal Contrastive Learning with Constraints and Self-Penalization. In the QUEST framework, we propose quaternion contrastive objectives and orthogonal constraints to extract sufficient unique information.